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Transcript of the interview Jacques Dubochet explains how his technique of water vitrification has allowed us to observe biomolecules like Zika and Salmonella in their natural state. Jacques Dubochet (born 8 June 1942) is a retired Swiss biophysicist. If you cool water it becomes ice. This breakthrough proved the technology’s potential.Joachim Frank made the technology generally applicable. Jacques Dubochet (born 8 June 1942) is a Swiss scientist, specialist of biophysics . Thank you very much indeed and once again congratulations.Did you find any typos in this text? It was not the kind of additional piece of education, it was a core programme in the study of biology and it still continues. In the past few years, scientific literature has been filled with images of everything from proteins that cause antibiotic resistance, to the surface of the Zika virus. [Laughs]JD: Well, ok. You can guess that today I have a lot of journalists and I do not miss to speak about that.AS: No, good. Lovely. Can we look forward to welcoming you to Stockholm in December?AS: Good, well we anticipate your arrival with great excitement. The electron microscope’s resolution has radically improved in the last few years, from mostly showing shapeless blobs to now being able to visualise proteins at atomic resolution. In the early 1980s, Dubochet succeeded in vitrifying water – he cooled water so rapidly that it solidified in its liquid form around a biological sample, allowing the biomolecules to retain their natural shape even in a vacuum.Following these discoveries, the electron microscope’s every nut and bolt have been optimised. Interview with Chemistry Laureate Jacques Dubochet on 6 December 2017 during the Nobel Week in Stockholm, Sweden.Jacques Dubochet answers the following questions (the links below lead to clip on YouTube):The 2017 Nobel Laureates met at the Grünewald Hall in the Stockholm Concert Hall in Stockholm for the traditional round-table discussion and TV program ‘Nobel Minds’. The desired atomic resolution was reached in 2013, and researchers can now routinely produce three-dimensional structures of biomolecules. Jacques Dubochet, A Reminiscence about Early Times of Vitreous Water in Electron Cryomicroscopy, Biophysical Journal, 110, 4, (756), (2016). He was born in Aigle, Switzerland.. Thank you for taking the time to report the errors by sending us an Tasked with a mission to manage Alfred Nobel's fortune and has ultimate responsibility for fulfilling the intentions of Nobel's will.For more than a century, these academic institutions have worked independently to select Nobel Laureates in each prize category.Several outreach organisations and activities have been developed to inspire generations and disseminate knowledge about the Nobel Prize. I’ve been, during the twenty years I was at the University of Lausanne, I have devoted a lot of effort to the curriculum – biology and society – and Lausanne at that time was unique in developing this curriculum for all our students. Jacques Dubochet - WikiMili, The Free Encyclopedia However, biochemical maps have long been filled with blank spaces because the available technology has had difficulty generating images of much of life’s molecular machinery. Jacques Dubochet, University of Lausanne, Department of Ecology and Evolution, Biophore, CH 1015 Lausanne, Switzerland.

Biophysicists Jacques Dubochet, Joachim Frank and Richard Henderson have won the Nobel Prize in chemistry for inventing new and better ways to see molecules. How do you feel about that and about the responsibility of scientists who interact with the public.JD: That’s interesting. Tel: +41 21 801 0349; fax: +41 21 692 4165; e‐mail: Jacques.Dubochet@unil.ch

He is a former researcher at the European Molecular Biology Laboratory in Heidelberg, Germany, and an honorary professor of biophysics at the University of Lausanne in Switzerland. Biochemistry is now facing an explosive development and is all set for an exciting future.Cool microscope technology revolutionises biochemistry The discussion was hosted by the BBC’s Zeinab Badawi.Telephone interview with Jacques Dubochet after the announcement of the 2017 Nobel Prize in Chemistry on 4 October 2017. Liquid water evaporates in the electron microscope’s vacuum, which makes the biomolecules collapse. It would be great if you could cool the water and immobilise the molecules, though keeping the structure because when it’s frozen, when it’s immobilised you can have it in the electron microscope and the water will not evaporate because in the electron microscope it must be under vacuum, and water at normal temperature evaporates. So in a way for twenty years you’ve been preparing for this role. He is honorary professor at the University of Lausanne and … The interviewer is Adam Smith, Chief Scientific Officer of Nobel Media.


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