© Copyright 2020. Joachim Frank was born in Siegen, Germany. (2015). Dr. Joachim Frank is a Professor of Biochemistry and Molecular Biophysics and of Biological Sciences at Columbia University, and Distinguished Professor of the State University of New York at Albany. View Joachim Frank’s profile on LinkedIn, the world's largest professional community. (A) Map of nonrotated ribosome (transparent) fitted with atomic models for both ribosome and EF-G. (B) Map of rotated ribosome at 3.6Å (transparent) fitted with atomic models. Joachim Frank is married and has two children.Fundamental processes of life are governed by a number of complicated molecules. Frank has worked at several institutions in the U.S. and Europe, including the Wadsworth Center, New York State Department of Health, State University of New York at Albany, Howard Hughes Medical Institute and Columbia University, where he has remained since 2008. However, electron beams destroy biological structures. (C) Superimposition of the maps of the 30S subunit (green for rotated) when two maps are aligned on the 50S subunits. 1.

(2015) Science Advances). Fifteen laureates were awarded in 2019, for achievements that have conferred the greatest benefit to humankind. Cryo-electron microscopy and single-particle reconstruction , studying the mechanism of protein biosynthesis and other molecular processes in the cell.Our laboratory conducts research on the mechanism of translation by the ribosome and on other processes involving molecular machines in the cell.The primary method of structural research is cryo-electron microscopy, based on the principle of forming a three-dimensional image by collecting and combining thousands of projections of the molecules embedded in a thin layer of ice.This method of “single-particle reconstruction” was pioneered in our lab, and is now widely used to study macromolecular interactions in a large range of systems.To this end, well-characterized, functionally active complexes are prepared In the application to the study of the ribosome and its interactions with mRNA, tRNA and a variety of factors during translations, we have made important discoveries about the dynamics of initiation, decoding, translocation, termination, and recycling in both prokaryotic and eukaryotic systems.The highest resolution of a functional bacterial ribosome complex that has been achieved is 6.7Å (see Fig.1).We continue to make efforts to advance the resolution by improving specimen preparation, data collection, and classification.Fig. Frank has worked at several institutions in the U.S. and Europe, including the Wadsworth Center, New York State Department of Health, State University of New York at Albany, Howard Hughes Medical Institute and Columbia University, where he has remained since 2008.

Sun, M., Li, W., Blomqvist, K., Das, S., Hashem, Y., Dvorin, J.D., and Frank, J. time-resolved cryo-EM. Dynamical features of the Plasmodium falciparum ribosome during translation. After studies at the universities in Freiburg and Munich, he received his doctor’s degree at the Technical University of Munich in 1970. (from Li et al. Prize motivation: "for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution." Er leistete wesentliche Beiträge zur Kryoelektronenmikroskopie von Einzelmolekülen und konnte mit dadurch ermöglichten elektronenmikroskopischen Aufnahmen wesentlich zur Aufklärung der Struktur und Funktion von Ribosomen beitragen. (D) Map-fitted structures of all tRNAs and EF-Gs at their respective positions shown in (C). The electron microscope, which uses electron beams instead of light, expands the possibilities to image these molecules. Journal: Nature. Author: Sandip Kaledhonkar, et al. Joachim Frank has dedicated his career to extending the vision of science to previously unseen layers and depths.

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